There may be a negative interaction between Losartan and alcohol. 114 Reviews about the risks, side effects and symptoms for taking Losartan while drinking alcohol. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Greiwe on losartan and alcohol: If used in moderation, it does not interact. Heavy alcohol use/withdrawal is associated with hypertension however. Other than alcohol, there's nothing else you specifically need to avoid while taking losartan. Just make sure you are eating a healthy, balanced diet to help your condition. Drinking alcohol can further lower your blood pressure and may increase certain side effects of losartan. Do not use potassium supplements or salt substitutes while you are taking this medicine, unless your doctor has told you to. If you are taking losartan you should avoid potassium-containing salt substitutes or over-the-counter potassium supplements without first talking to your doctor. Summary. Drug interactions are reported among people who take Losartan potassium and Alcohol together. This study is created by eHealthMe based on reports of 10 people who take Losartan potassium and Alcohol from FDA, and is updated regularly. It is not a good idea to drink alcohol while taking losartan potassium tablets. This is because of the immense stress that both of these put onto the liver. Alcohol can also increase the blood pressure-lowering effect of losartan. This increases the risk of your blood pressure getting too low. This increases the risk of your blood pressure getting too. This may be a normal reaction of your body since hot and spicy meals as well as alcohol may cause dilation of blood vessels and increase the blood flow to the area which causes the flushing. However, alcohol can increase the side effects of losartan. The common side effects with losartan are dizziness, headache, insomnia, muscle pain, cough, fatigue, orthostatic hypotension, and.